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Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials, which guide the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and follow-up. The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.